GO cellular component ontology term - GO:0033290 - eukaryotic 48S preinitiation complex
Term summary
- ID
- GO:0033290
- Name
- eukaryotic 48S preinitiation complex
- Ontology or CV name
- GO cellular component
- Definition
- The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.
