GO cellular component ontology term - GO:0034098 - VCP-NPL4-UFD1 AAA ATPase complex
Term summary
- ID
- GO:0034098
- Name
- VCP-NPL4-UFD1 AAA ATPase complex
- Ontology or CV name
- GO cellular component
- Definition
- A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
