GO biological process ontology term - GO:0036503 - ERAD quality control pathway
Term summary
- ID
- GO:0036503
- Name
- ERAD quality control pathway
- Ontology or CV name
- GO biological process
- Definition
- The protein catabolic pathway which constitutively monitors and targets misfolded/aberrant endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
