GO cellular component ontology term - GO:0043224 - nuclear SCF ubiquitin ligase complex
Term summary
- ID
- GO:0043224
- Name
- nuclear SCF ubiquitin ligase complex
- Ontology or CV name
- GO cellular component
- Definition
- A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
