GO molecular function ontology term - GO:0051880 - G-quadruplex DNA binding
Term summary
- ID
- GO:0051880
- Name
- G-quadruplex DNA binding
- Ontology or CV name
- GO molecular function
- Definition
- Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
