GO molecular function ontology term - GO:0061630 - ubiquitin protein ligase activity
Term summary
- ID
- GO:0061630
- Name
- ubiquitin protein ligase activity
- Ontology or CV name
- GO molecular function
- Definition
- Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
