Disease association ontology term - MONDO:0019148 - Wolman disease
Term summary
- ID
- MONDO:0019148
- Name
- Wolman disease
- Ontology or CV name
- Disease association
- Definition
- Wolman disease represents the most severe manifestation of lysosomal acid lipase deficiency. Milder phenotypes as a whole are referred to as cholesterol ester storage disease. The acid lipase enzyme plays an essential role in lysosomal hydrolysis of both esterified cholesterol and triglycerides of lipoproteic origin. In Wolman disease, the rarest form of acid lipase deficiency, these lipids accumulate in most tissues.
